RESEARCH
Multi-scale Quantitative Approaches to Decode Cellular, Developmental and Cancer Dynamics
Experimental and computational approaches towards exploring spatiotemporal dynamics of biological systems.
This collection focuses on experimental and/or computational approaches aimed at understanding spatiotemporal dynamics observed in diverse biological processes, at intracellular, cellular and tissue-scales. The articles collated here showcase quantitative approaches to collect, analyze and interpret real-time high-throughput data in biological systems at multiple length and time scales, moving towards a predictive understanding of diverse physiological and pathological situations. They apply different biophysical, computational modeling and statistical tools to address questions related to, but not limited to, understanding
- How cells come together to form tissues, organs and organisms (cell-fate decisions, impact of cell-cell communication, collective cell behavior etc.)
- How tissue integrity is maintained during homeostasis (methods to elucidate principles of self-organization of tissues in vitro and in vivo, stem cell differentiation, cell-matrix and cell-cell interactions in enabling tissue integrity etc.)
- How developmental/homeostatic scenarios are dysregulated in diseases such as cancer (perturbed cell-cell and cell-matrix interactions, mechanisms leading to compromised tissue integrity etc.)
Edited by:
Dr. Mohit Kumar Jolly (Indian Institute of Science, India)
Dr. Kyra Campbell (Sheffield University, UK)
Dr. Sundar Naganathan (École polytechnique fédérale de Lausanne (EPFL), Switzerland)
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Emergence of Spatial Scales and Macroscopic Tissue Dynamics in Active Epithelial Monolayers
Padmalochini Selvamani; Raghunath Chelakkot; Amitabha Nandi; Mandar M. Inamdar
Cells Tissues Organs (DOI:10.1159/000528501) -
Coupled Mutual Inhibition and Mutual Activation Motifs as Tools for Cell-Fate Control
Burhanuddin Sabuwala; Kishore Hari; Abhishek Shanmuga Vengatasalam; Mohit Kumar Jolly
Cells Tissues Organs (DOI:10.1159/000529558) -
A Multistep Tumor Growth Model of High Grade Serous Ovarian Carcinoma Identifies Hypoxia Associated Signatures
Madhuri H. More; Sagar S. Varankar; Rutika R. Naik; Rahul D. Dhake; Pritha Ray; Rahul M. Bankar; Avinash M. Mali; Ayalur Raghu Subbalakshmi; Priyanka Chakraborty; Mohit Kumar Jolly; Sharmila A. Bapat
Cells Tissues Organs (DOI:10.1159/000526432) -
Using optogenetics to investigate the shared mechanisms of apical-basal polarity and mitosis
Helena A. Crellin; Clare E. Buckley
Cells Tissues Organs (DOI:10.1159/000528796) -
Prediction of Golgi Polarity in Collectively Migrating Epithelial Cells Using Graph Neural Network
Purnati Khuntia; Tamal Das
Cells Tissues Organs (DOI:10.1159/000528354) -
Assessing combinatorial diversity of aureochrome bZIPs through genome-wide screening
Madhurima Khamaru; Deep Nath; Devrani Mitra; Soumen Roy
Cells Tissues Organs (DOI:10.1159/000527593) -
On the Variability in Cell and Nucleus Shapes
Anusha Devulapally; Varun Parekh; Clint Pazhayidam George; Sreenath Balakrishnan
Cells Tissues Organs (DOI:10.1159/000527825) -
Nuclear biophysical changes during human melanoma plasticity
Maria Chiara Lionetti; Maria Rita Fumagalli; Caterina A.M. La Porta
Cells Tissues Organs (DOI:10.1159/000528601)
